GHK-CU 50mg

GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper) is a naturally occurring tripeptide-copper complex with the amino acid sequence Gly-His-Lys that demonstrates extraordinary regenerative, protective, and anti-aging properties across multiple tissue types and biological systems. First isolated from human plasma by Loren Pickart in 1973 during research on components that could stimulate liver regeneration, GHK was initially recognized for its ability to promote tissue repair and remodeling.

Subsequent research revealed that GHK has exceptionally high binding affinity for copper ions (Cu²⁺), forming a stable chelate complex (GHK-Cu) that is the biologically active form responsible for the peptide’s remarkable effects.

Age-Related Decline

In the body, GHK-Cu naturally occurs at concentrations of approximately 200 ng/mL in plasma at age 20, but these levels decline progressively with age to less than 80 ng/mL by age 60 – this age-related decline correlates with decreased tissue repair capacity, skin aging, and impaired regenerative responses, leading to the hypothesis that GHK-Cu decline contributes to aging phenotypes and that restoration of youthful levels through supplementation could have anti-aging benefits.

Diverse Biological Activities

The peptide’s biological activities are remarkably diverse and include stimulation of collagen and glycosaminoglycan synthesis (critical for skin, connective tissue, and wound healing), activation of wound healing mechanisms, promotion of blood vessel formation (angiogenesis) to support tissue repair and regeneration, anti-inflammatory effects that resolve excessive inflammation while supporting beneficial healing responses, antioxidant and protective effects against oxidative damage and toxic compounds, attraction of immune and repair cells to sites of injury, remodeling of extracellular matrix through regulated metalloproteinase activity, stimulation of nerve outgrowth and regeneration, and even modulation of gene expression in patterns that reverse age-related changes and restore more youthful cellular function.